Diethyl Ether → 1-Phenethyl-4-acetamidopyridinium bromide

HRID 1730343Notes

Reaction equation

HRID 1730343 reaction equation
[CH2:1]([Br:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:10]([NH:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1)(=[O:12])[CH3:11].CCOCC>C(O)C>[Br-:9].[CH2:1]([N+:17]1[CH:18]=[CH:19][C:14]([NH:13][C:10](=[O:12])[CH3:11])=[CH:15][CH:16]=1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 7666Phenethyl bromideHCID 21288N-Pyridin-4-ylacetamide

Product 1

HCID 214305751-Phenethyl-4-acetamidopyridinium bromide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of phenethyl bromide and 4-acetamidopyridine in absolute ethanol was heated under reflux, cooled, treated with ether and allowed tostand overnight to give 1-phenethyl-4-acetamidopyridinium bromide.

Workup

  1. temperatureunder reflux
  2. temperaturecooled

Sources & evidence

ORD record
ord-a4972e8aec0e47c7914a868ab2b93f31
Source dataset
uspto-grants-1976_11
Patent number
US03992389

Reaction notes

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