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Potassium Carbonate → 1-[2-(2,6-Dichlorophenyl)ethyl]-4-benzamidopiperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-4-Piperidylbenzamide | HCID 118120 | — |
| 反応物 | 2-(2-Bromoethyl)-1,3-dichlorobenzene | HCID 13480195 | — |
| 生成物 | 1-[2-(2,6-Dichlorophenyl)ethyl]-4-benzamidopiperidine | HCID 21413271 | 41.1% |
反応手順
2-(2,6-Dichlorophenyl)ethyl bromide (674 mg.) was reacted with 4-benzamidopiperidine (547 mg.) in the presence of anhydrous potassium carbonate (736 mg.) following the procedure of Example 37 to give the title compound as the hydrochloride (412 mg) m.p. 285.7° C after crystallisation from ethanolic hydrogen chloride and ether. (Found: C, 58.0; H, 5.6; N, 6.7. C20H22Cl2N2O. HCl requires C, 58.05; H, 5.6; N, 6.8%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03992389 |
| 出典データセット | uspto-grants-1976_11 |
| ORD ID | ord-12a075ed9bf74a95a8d9c563ab5859aa |
| 出典メモ | uspto-grants-1976_11 |