HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Benzamido-1-[4-(4-tert-butyl-phenyl)-4-oxobutyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-4-Piperidylbenzamide | HCID 118120 | — |
| Reactant | 4'-tert-Butyl-4-chlorobutyrophenone | HCID 2723694 | — |
| Product | 4-Benzamido-1-[4-(4-tert-butyl-phenyl)-4-oxobutyl]piperidine | HCID 21430612 | 57.4% |
Reaction Steps
4-Chloro-4'-tert-butylbutyrophenone (3.58 g.), 4-benzamidopiperidine (3.06 g.) and anhydrous potassium carbonate 2.67 g.) were reacted together in the manner of Example 68 to give the title compound (3.495 g.) as the hydrochloride, colourless microcrystals, m.p. 268.0°. Analysis: Found: C, 70.50; H, 8.14; N, 6.29. C26H34N2O2.HCl requires C, 70.48; H, 7.96; N, 6.32%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03992389 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-45807a92fd964bf497bab8e3d6f5a7e5 |
| Source note | uspto-grants-1976_11 |