HCID 12947027, compound → HCID 178521283, compound

HRID 1730395Notes

Reaction equation

HRID 1730395 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=S)[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[CH:20]=1.[C:23]1(=[O:38])[N:27]([CH2:28][C:29](=[O:32])[CH2:30][NH2:31])[C:26](=[O:33])[C:25]2=[CH:34][CH:35]=[CH:36][CH:37]=[C:24]12>C(O)C>[F:1][C:2]([F:22])([F:21])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:31][CH2:30][C:29]([CH2:28][N:27]3[C:23](=[O:38])[C:24]4=[CH:37][CH:36]=[CH:35][CH:34]=[C:25]4[C:26]3=[O:33])=[O:32])[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[CH:20]=1

Participants

4

Reactant 2

HCID 12947027HCID 12947027, compoundHCID 21497500HCID 21497500, compound

Product 1

HCID 178521283HCID 178521283, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in example 12, 7-trifluoromethyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione is heated with (3-phthalimidoacetonyl)amine, ethylene ketal in ethanol to give 7-trifluoromethyl-5-phenyl-2-[(3-phthalimidoacetonyl)amino]-3H-1,4-benzodiazepine, ethylene ketal.

Sources & evidence

ORD record
ord-082b4e177c504f0883122d01bf3269c6
Source dataset
uspto-grants-1976_11
Patent number
US03992408

Reaction notes

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