Sulfuric Acid → HCID 21497534, compound

HRID 1730397Notes

Reaction equation

[F:1][C:2]([F:37])([F:36])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][CH2:14][C:15]([CH2:17][N:18]3[C:22](=[O:23])[C:21]4=[CH:24][CH:25]=[CH:26][CH:27]=[C:20]4[C:19]3=[O:28])=O)[CH2:10][N:9]=[C:8]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:7]=2[CH:35]=1.S(=O)(=O)(O)O>>[F:1][C:2]([F:37])([F:36])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:15]([CH2:17][N:18]4[C:19](=[O:28])[C:20]5=[CH:27][CH:26]=[CH:25][CH:24]=[C:21]5[C:22]4=[O:23])=[CH:14][N:13]=[C:11]3[CH2:10][N:9]=[C:8]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:7]=2[CH:35]=1

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 178521283HCID 178521283, compound

Product 1

HCID 21497534HCID 21497534, compound

Procedure

In the manner given in Example 20, 7-trifluoromethyl-5-phenyl-2-[(3-phthalimidoacetonyl)amino]-3H-1,4-benzodiazepine, ethylene ketal is treated with concentrated sulfuric acid, then quenched to give after neutralization, 8-trifluoromethyl-1-(phthalimidomethyl)-6-phenyl-4H-imidazo-[1,2-a][1,4]benzodiazepine.

Workup

customquenched

Sources & evidence

ORD record: ord-b49c3fcb13db45e7925a1b6788f673a0
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03992408

Reaction notes

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