Sulfuric Acid → HCID 21497545, compound

HRID 1730398Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][CH2:13][C:14]([CH2:16][N:17]3[C:21](=[O:22])[C:20]4=[CH:23][CH:24]=[CH:25][CH:26]=[C:19]4[C:18]3=[O:27])=O)[CH2:9][N:8]=[C:7]([C:28]3[C:33]([F:34])=[CH:32][CH:31]=[CH:30][C:29]=3[F:35])[C:6]=2[CH:36]=1.S(=O)(=O)(O)O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:14]([CH2:16][N:17]4[C:21](=[O:22])[C:20]5=[CH:23][CH:24]=[CH:25][CH:26]=[C:19]5[C:18]4=[O:27])=[CH:13][N:12]=[C:10]3[CH2:9][N:8]=[C:7]([C:28]3[C:33]([F:34])=[CH:32][CH:31]=[CH:30][C:29]=3[F:35])[C:6]=2[CH:36]=1

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 178521285HCID 178521285, compound

Product 1

HCID 21497545HCID 21497545, compound

Procedure

In the manner given in example 20, 7-chloro-5-(2,6-difluorophenyl)-2-[(3-phthalimidoacetonyl)amino]-3H-1,4-benzodiazepine, ethylene ketal is treated with concentrated sulfuric acid, then quenched to give after neutralization, 8-chloro-1-(phthalimidomethyl)-6-(2,6-difluorophenyl)-4H-imidazo[1,2-a][1,4]benzodiazepine.

Workup

customquenched

Sources & evidence

ORD record: ord-e8d81a3b884c4a3fb28240bded109bc5
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03992408

Reaction notes

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