Sodium Hydroxide → HCID 54084847, compound

HRID 1730418Notes

Reaction equation

HRID 1730418 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[C:20]([S:21](=[O:24])(=[O:23])[NH2:22])=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[NH:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+]>>[NH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[C:20]([S:21](=[O:24])(=[O:23])[NH2:22])=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[NH:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54131094HCID 54131094, compound

Product 1

HCID 54084847HCID 54084847, compound

Procedure

The mixture of 2.2 g of 4-(4-acetamidophenylmercapto)-3-benzylamino-5-sulfamoylbenzoic acid and 22ml of 2N aqueous sodium hydroxide is refluxed for one hour under nitrogen. After cooling it is filtered, the filtrate acidified with glacial acetic acid to pH = 4. The precipitate formed is filtered off and recrystallized from 50% aqueous ethanol, to yield the 4-(4-aminophenylmercapto)-3-benzylamino-5-sulfamoylbenzoic acid melting at254°-256°.

Workup

  1. temperatureis refluxed for one hour under nitrogen
  2. temperatureAfter cooling it
  3. filtrationis filtered
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. customrecrystallized from 50% aqueous ethanol

Sources & evidence

ORD record
ord-890e4ae6a9664ed4b7169f9f1ca6d65b
Source dataset
uspto-grants-1976_11
Patent number
US03992440

Reaction notes

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