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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1730459Generated: October 31, 2026

Potassium Hydroxide → 4-Chloro-alpha-(2,6-difluorophenyl)-o-toluidine

https://huagongshe.com/reaction/1730459

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant4-Chloro-2-(2,6-difluorobenzoyl)anilineHCID 15563835—
SolventDiethylene GlycolHCID 8117—
Product4-Chloro-alpha-(2,6-difluorophenyl)-o-toluidineHCID 21497373—

Reaction Steps

In the manner given in Preparation 11, 2-amino-5-chloro-2',6'-difluorobenzophenone is refluxed with potassium hydroxide in diethylene glycol to give 4-chloro-α-(2,6-difluorophenyl)-o-toluidene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03992400
Source datasetuspto-grants-1976_11
ORD IDord-2f219c4825c34cafa0a797d0818aba92
Source noteuspto-grants-1976_11