Potassium Hydroxide → 4-(Trifluoromethyl)-alpha-phenyl-o-toluidine

HRID 1730465Notes

Reaction equation

[NH2:1][C:2]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[OH-].[K+]>>[F:17][C:16]([F:18])([F:19])[C:13]1[CH:12]=[C:3]([CH2:4][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2](=[CH:15][CH:14]=1)[NH2:1]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 13014169(2-Amino-5-(trifluoromethyl)phenyl)(phenyl)methanone

Product 1

HCID 200619714-(Trifluoromethyl)-alpha-phenyl-o-toluidine

Procedure

In the manner given in Preparation 11, 2-amino-5-(trifluoromethyl)benzophenone is refluxed with potassium hydroxide in diethylene glyclol to give 4-(trifluoromethyl)-α-phenyl-o-toluidine.

Sources & evidence

ORD record: ord-fc26005a112442a7acf49219a777e561
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03992400

Reaction notes

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