HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → 5-Methyl-1-[alpha-(o-chlorophenyl)-o-tolyl]imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | (2-Methyl-1,3-dioxolan-2-yl)methanamine | HCID 12434663 | — |
| Reactant | 2-[(2-Chlorophenyl)methyl]aniline | HCID 13426664 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Product | 5-Methyl-1-[alpha-(o-chlorophenyl)-o-tolyl]imidazole | HCID 21497387 | — |
Reaction Steps
In the manner given in Example 3, α-(o-chlorophenyl)-o-toluidine is reacted with triethyl orthoformate, the resulting oil is heated with 2-methyl-2-(aminomethyl)-1,3-dioxolane, and the resulting product treated with titanium tetrachloride to give 5-methyl-1-[α-(o-chlorophenyl)-o-tolyl]imidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03992400 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-cc13805fd1e8428d87430670069f7e86 |
| Source note | uspto-grants-1976_11 |