2-Aminopyridine → HCID 178522104, compound

HRID 1730484Notes

Reaction equation

HRID 1730484 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16](Cl)=[O:17].[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1>>[N:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[NH:19][C:16]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[OH:1])=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]([F:15])([F:14])[F:13])=[O:17]

Participants

3

Reactant 2

HCID 104392-AminopyridineHCID 178521124HCID 178521124, compound

Product 1

HCID 178522104HCID 178522104, compound

Procedure

Using the procedure of Step B of Example 1, 4-hydroxy- 8-trifluoromethyl-3-quinoline carboxylic acid chloride and 2-amino-pyridine were reacted to obtain N-[2-pyridinyl]-4 -hydroxy-8-trifluoromethyl-3-quinoline-carboxamide melting at 335°-336° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6afc9fcc14f34827b33e1b37a2097838
Source dataset
uspto-grants-1976_11
Patent number
US03992540

Reaction notes

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