2-Aminothiazole → HCID 178522563, compound

Participants

Reaction Steps

A solution of 2.9 g of 2-amino-thiazole in 20 ml of pyridine was added at room temperature to a suspension of 7 g of the acid chloride of Step A in 90 ml of pyridine and the mixture was stirred for 16 hours at room temperature. The pyridine was evaporated and a mixture of potassium carbonate solution and water was added to the residue. The reaction mixture was stirred and vacuum filtered and the recovered precipitate was washed and dried. The product was crystallized from dimethylformamide to obtain 6.5 g of N-[2-thiazolyl] -4-hydroxy-8-chloro-3-quinoline-carboxamide melting above 369° C.

Provenance & Evidence