1-Butanol → HCID 21498231, compound

HRID 1730492Notes

Reaction equation

HRID 1730492 reaction equation
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][C:9]3C[C:10]=3[CH:11]=2)[C:6](O)=[C:5](O)[N:4]=1)[NH2:2].[CH:16]([O-])([O-:20])[O:17]CC.[CH2:22](O)CCC>>[CH2:16]1[O:20][C:10]2[CH:11]=[C:12]3[C:7]([CH:6]=[CH:5][N:4]4[CH:22]=[N:2][N:1]=[C:3]43)=[CH:8][C:9]=2[O:17]1

Participants

4

Reactant 3

HCID 2631-ButanolHCID 53630039EthylorthoformateHCID 178514358HCID 178514358, compound

Product 1

HCID 21498231HCID 21498231, compoundYield 71%

Procedure

1-Hydrazino-6,7-methylenedioxylisoquinoline (25 g.) and 10 ml. of ethyl orthoformate were allowed to reflux for five hours in 70 ml. of 1-butanol.Evaporation of the solvent in vacuo and recrystallization from toluene provided the product in a yield of 71%; m.p. 267°-269°C.

Workup

  1. temperatureto reflux for five hours in 70 ml
  2. customEvaporation of the solvent
  3. customin vacuo and recrystallization from toluene
  4. customprovided the product in a yield of 71%

Sources & evidence

ORD record
ord-bf1b5141eb2747bd8f4c893e55504cc8
Source dataset
uspto-grants-1976_11
Patent number
US03992539

Reaction notes

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