Piperazine, 1-[4-[(7-chloro-4-quinolinyl)amino]benzoyl]-4-methyl- → HCID 21399778, compound

Participants

Reaction Steps

Similarly, following the above procedure but replacing the 1-[p-[ (7-chloro-4-quinolyl)amino]benzoyl]-4-methylpiperazine as used therein with an equal molar proportion of 1-[p-[ (4-quinolyl)amino]benzoyl]-4-methylpiperazine; 1-[p-[(7-chloro- 4-quinolyl)amino]benzoyl]-4-butylpiperazine; 1-[p-[ (7-chloro-4-quinolyl)amino]benzoyl]-4-benzylpiperazine; 1-[p-[(6-methoxy-4-quinolyl)amino]benzoyl]-4-methylpiperazine; 1-[p-[(5-isobutoxy-4-quinolyl)amino]benzoyl]-4-methylpiperazine; 1-[p-[(7-methyl-4-quinolyl)amino]benzoyl]- 4-methylpiperazine; 1-[p-[(6-isopropyl-4-quinolyl)amino] benzoyl]-4-methylpiperazine; 1-[p-[[(7-trifluoromethyl)- 4-quinolyl]amino]benzoyl]-4-isobutylpiperazine; 1-[p-[ [(7-trifluoromethyl)-4-quinolyl]amino]benzoyl]-4-benzylpiperazine; 1-[p-[[(7-trichloromethyl)-4-quinolyl]amino] benzoyl]-4-methylpiperazine; and 1-[p-[(7-chloro-4 -quinolyl)-N-ethylamino]benzoyl]-4-methylpiperazine,respectively, there is obtained 1-[p-[(4 -quinolyl)amino]benzoyl]-4-methylpiperazine-4-oxide; 1-[p-[(7-chloro-4-quinolyl)amino]benzoyl] -4-butylpiperazine-4-oxide; 1-[p-[(7-chloro-4-quinolyl)amino] benzoyl]-4-benzylpiperazine-4-oxide; 1-[p-[(6-methoxy- 4-quinolyl)amino]benzoyl]-4-methylpiperazine-4-oxide; 1-[p-[(5-isobutoxy-4-quinolyl)amino]benzoyl]-4-methylpiperazine-4-oxide; 1-[p-[(7-methyl-4-quinolyl)amino]benzoyl]- 4-methylpiperazine-4-oxide; 1-[p-[(6-isopropyl-4 -quinolyl)amino]benzoyl]-4-methylpiperazine-4-oxide; 1-[p-[[(7-trifluoromethyl)-4-quinolyl]amino]benzoyl]-4-isobutylpiperazine-4-oxide; 1-[p-[[(7-trifluoromethyl)-4-quinolyl]amino] benzoyl]-4-benzylpiperazine-4-oxide; 1-[p-[[(7-trichloromethyl)- 4-quinolyl]amino]benzoyl]-4-methylpiperazine-4-oxide; and 1-[p-[(7-chloro-4-quinolyl)-N-ethylamino] benzoyl]-4-methylpiperazine-4-oxide, respectively.

Provenance & Evidence