HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-methylpyridine → UH-A 46 XX
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-methylpyridine | HCID 1533 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide | HCID 54690651 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | UH-A 46 XX | HCID 54692988 | 58% |
Reaction Steps
5.0 gm (0.016 mol) of 4-hydroxy-2-methyl-2H-naphtho[ 2,1-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1-dioxide were reacted with 2.2 gm (0.02 mol) of 2-amino-4-methylpyridine in 220 ml of xylene analogous to Example 10, and yielded 3.5 gm (58% of theory) of 4-hydroxy-2-methyl-N-(4-methyl-2-pyridyl)-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide, m.p. 221° C (decomp.; from ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03992535 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-d7a76d0387ed4a24ada61495e1e17e10 |
| Source note | uspto-grants-1976_11 |