HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-Hydroxypyridine → 4-Hydroxy-N-(3-hydroxy-2-pyridyl)-2-methyl-2H-naphtho[2,1-e]1,2-thiazine-3-carboxamide-1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-Hydroxypyridine | HCID 28114 | — |
| Reactant | 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide | HCID 54690651 | — |
| Product | 4-Hydroxy-N-(3-hydroxy-2-pyridyl)-2-methyl-2H-naphtho[2,1-e]1,2-thiazine-3-carboxamide-1,1-dioxide | HCID 54695947 | 40% |
Reaction Steps
4-Hydroxy-N-(3-hydroxy-2-pyridyl)-2-methyl-2H-naphtho[2,1-e]1,2-thiazine-3-carboxamide-1,1-dioxide was prepared analogous to Example 1 from 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide and 2-amino-3-hydroxy-pyridine. Yield: 40% of theory; m.p. 255° C (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03992535 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-2ddf5b0f24e1449fa394a8731089fe92 |
| Source note | uspto-grants-1976_11 |