Aminopyrazine → HCID 54695959, compound

Participants

Reaction Steps

A mixture consisting of 4.8 gm (0.015 mol) of 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide, 2.1 gm (0.022 mol) of aminopyrazine and 200 ml of dry xylene was refluxed for 8 hours in a Soxhlet apparatus equipped with 4-A-molecular sieve. Then, another 0.5 gm of aminopyrazine was added, the mixture was refluxed for 8 hours more, and then allowed to cool and stand overnight. The precipitate formed thereby was suctionfiltered off, and thefiltrate was evaporated in vacuo. The combined precipitate and evaporation residue was recyrstallized from ethyl acetate, yielding 3.0 gm (52% of theory) of 4-hydroxy-2-methyl-N-pyrazinyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1dioxide, m.p. 245° C (decomp.).

Provenance & Evidence