2-Amino-4-methylthiazole → HCID 54695969, compound

Participants

Reaction Steps

5.0 gm (0.016 mol) of 4-hydroxy-2-methyl-2H-naphtho [2,1-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1-dioxide were reacted with 2.75 gm (0.025 mol) of 2-amino-4-methyl-thiazole in 200 ml ofxylene analogous to Example 1 and yielded 2.52 gm (40% of theory) of 4-hydroxy-2-methyl-N-(4-methyl-2-thiazolyl)-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide, m.p. 177° C (decomp.; from ethyl acetate).

Provenance & Evidence