HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Ethyl-4-methylthiazol-2-amine → N-(5-Ethyl-4-methyl-2-thiazolyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2thiazine-3-carboxamide-1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Ethyl-4-methylthiazol-2-amine | HCID 12735956 | — |
| Reactant | 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide | HCID 54690651 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(5-Ethyl-4-methyl-2-thiazolyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2thiazine-3-carboxamide-1,1-dioxide | HCID 54695951 | 63% |
Reaction Steps
N-(5-Ethyl-4-methyl-2-thiazolyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2thiazine-3-carboxamide-1,1-dioxide was prepared analogous to Example 22 from 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide and 2-amino-5-ethyl-4-methyl-thiazole. Yield: 63% of theory; m.p. 253°-255° C (decomp.; from ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03992535 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-cf136d83c63d48afa36e62f58e4aefca |
| Source note | uspto-grants-1976_11 |