3-Amino-5-methylisoxazole → 4-Hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H-naphtho [2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

Participants

Reaction Steps

4.8 gm (0.015 mol) of 4-hydroxy-2-methyl-2H-naphtho [2,1-e]-1,2thiazine-3-carboxylic acid methyl ester-1,1-dioxide were reacted with 2.11 gm (0.021 mol) of 3-amino-5-methyl-isoxazole in 250 ml of dry xylene analogous to Example 1, yielding 3.3 gm (57% of theory) of 4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide, m.p. 253° C, after recrystallization from xylene.

Provenance & Evidence