Aniline → HCID 54695934, compound

Participants

Reaction Steps

A mixture of 9.58 gm (0.03 mol) of 4-hydroxy-2H-naphtho[2,1-e]-1,2thiazine-3-carboxylic acid methyl ester-1,1-dioxide, 3.72 gm (0.04 mol) of aniline and 150 ml of anhydrous xylene was refluxed for 10 hours in a Soxhlet apparatus equipped with a 4-A-molecular sieve. After cooling, the reaction mixture was allowed to stand overnight, whereupon the precipitaed crystals were suction-filtered off and recrystallized from ethylene chloride. 6.10 gm (55% of theory) of 4-hydroxy-N-phenyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide, m.p. 260°-262° C, were obtained.

Provenance & Evidence