HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4,5-dimethyl-1,3-thiazole → N-(4,5-Dimethyl-2-thiazolyl)-4-hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4,5-dimethyl-1,3-thiazole | HCID 73238 | — |
| Reactant | 4-hydroxy-2H-naphtho[2,1-e]-1,2thiazine-3-carboxylic acid methyl ester-1,1-dioxide | HCID 54719390 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | N-(4,5-Dimethyl-2-thiazolyl)-4-hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide | HCID 54695961 | 35% |
Reaction Steps
N-(4,5-Dimethyl-2-thiazolyl)-4-hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide was prepared analogous to Example 37 from 4-hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1-dioxide and 2-amino-4,5-dimethyl-thiazole. Yield: 35% of theory;m.p. 253° C (decomp.; from xylene).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03992535 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-4d503712cc674033ad5731a18c0b3c59 |
| Source note | uspto-grants-1976_11 |