2-Aminothiazole → 2-ethyl-4-hydroxy-N-(2-thiazolyl)-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

Participants

Reaction Steps

3.3 gm (0.01 mol) of 2-ethyl-4-hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1-dioxide and 1.5 gm (0.015 mol) of 2-aminothiazole were reacted in 150 ml of xylene analogous to Example 40, yielding 1.0 gm (25% of theory) or 2-ethyl-4-hydroxy-N-(2-thiazolyl)-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide, m.p. 261°-262° C (decomp.), after recrystallization from ethyl acetate.

Provenance & Evidence