HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloroaniline → N-(3-Chloro-phenyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloroaniline | HCID 7932 | — |
| Reactant | 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid ethyl ester-1,1-dioxide | HCID 68141912 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | N-(3-Chloro-phenyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide | HCID 54695958 | 71% |
Reaction Steps
N-(3-Chloro-phenyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide was prepared analogous to Example 1 from 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid ethyl ester-1,1-dioxide and 3-chloroaniline. Yield: 71% of theory; m.p. 248°-249° C (decomp.; from ethylene chloride).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03992535 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-107e738f52ec414d9454edc0be764687 |
| Source note | uspto-grants-1976_11 |