HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroacetate → 3-Oxo-naphth[2,1-d]isothiazoline-2-acetic acid ethyl ester-1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroacetate | HCID 7751 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 1H-1lambda~6~-Naphtho[2,1-d][1,2]thiazole-1,1,3(2H)-trione | HCID 12421514 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Oxo-naphth[2,1-d]isothiazoline-2-acetic acid ethyl ester-1,1-dioxide | HCID 12421515 | 72% |
Reaction Steps
3-Oxo-naphth[2,1-d]isothiazoline-2-acetic acid ethyl ester -1,1-dioxide was prepared analogous to Example 1a from the sodium salt of 3-oxo-naphth[2,1-d]isothiazoline-1,1-dioxide and chloro-acetic acid ethyl ester. Yield: 72% of theory; m.p. 149- 150.5° C (from ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03992535 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-3e7481bec7cb474f87ede5065056a779 |
| Source note | uspto-grants-1976_11 |