Methyl iodide → N-(3-Chloro-phenyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

HRID 1730570Notes

Reaction equation

HRID 1730570 reaction equation
[Cl:1][C:2]1N=CN=[C:4]([NH:8][C:9]([C:11]2[N:12]([CH3:28])[S:13](=[O:27])(=[O:26])[C:14]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH:19]=[CH:18][C:15]=3[C:16]=2[OH:17])=[O:10])[CH:3]=1.Cl[C:30]1N=CN=[C:32](NC(C2NS(=O)(=O)C3C4C(=CC=CC=4)C=CC=3C=2O)=O)[CH:31]=1.CI>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([C:11]2[N:12]([CH3:28])[S:13](=[O:26])(=[O:27])[C:14]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH:19]=[CH:18][C:15]=3[C:16]=2[OH:17])=[O:10])[CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 54695919N-(6-Chloro-4-pyrimidyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxideHCID 86734201N-(6-chloro-4-pyrimidyl)-4-hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

Product 1

HCID 54695958N-(3-Chloro-phenyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

Procedure

N-(6-Chloro-4-pyrimidyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide, m.p. 263° C (decomp.), from N-(6-chloro-4-pyrimidyl)-4-hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide and methyl iodide.

Sources & evidence

ORD record
ord-22316dc2ed9e4c72b1524f2866ad5893
Source dataset
uspto-grants-1976_11
Patent number
US03992535

Reaction notes

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