反应详情

2-Chloro-5-chlorosulfonyl benzoic acid, 3.5 g. (0.014 mole), is added to a solution of 2-(p-chlorophenyl)ethylamine, 6.5 g. (0.042 mole) in 25 ml. methylene chloride. The resulting slurry is stirred overnight and filteredto recover 9.7 g. of residue. This is recrystallized three times from aqueous isopropanol, then dissolved in 1N aqueous sodium hydroxide, washedthree times with ether, and then acidified with conc. hydrochloric acid. The resulting precipitate is recrystallized twice from aqueous isopropanolto yield the desired product, m.p. 176°- 178° C.

1. customfilteredto recover 9.7 g
2. customThis is recrystallized three times from aqueous isopropanol
3. dissolutiondissolved in 1N aqueous sodium hydroxide
4. customThe resulting precipitate is recrystallized twice from aqueous isopropanolto