Thiomorpholine → HCID 20505943, compound

HRID 1730598Notes

Reaction equation

HRID 1730598 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:15]1[CH2:20][CH2:19][S:18][CH2:17][CH2:16]1>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:15]2[CH2:20][CH2:19][S:18][CH2:17][CH2:16]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 67164ThiomorpholineHCID 34272982-Bromo-5-(chlorosulfonyl)benzoic acid

Product 1

HCID 20505943HCID 20505943, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This product is prepared by the reaction of 2-bromo-5-chlorosulfonyl benzoic acid with excess thiomorpholine in methylene chloride. The product, m.p. 195°-197.5° C., is purified by solution in aqueous sodium hydroxide, crystallization by acidifying the basic solution, and recrystallization from acetone-hexane.

Workup

  1. customThe product, m.p. 195°-197.5° C., is purified by solution in aqueous sodium hydroxide
  2. customcrystallization
  3. customthe basic solution, and recrystallization from acetone-hexane

Sources & evidence

ORD record
ord-47303605ba00492c9857bef80a0b7fc9
Source dataset
uspto-grants-1976_11
Patent number
US03992441

Reaction notes

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