HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylpiperidine → 3-Chloro-5-(3-methylpiperidinosulfonyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylpiperidine | HCID 79081 | — |
| Reactant | 3-Chloro-5-(chlorosulfonyl)benzoic acid | HCID 3861275 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Chloro-5-(3-methylpiperidinosulfonyl)benzoic acid | HCID 20505972 | — |
Reaction Steps
The procedure of Example 43 is repeated, starting with 5 g. (0.05 mole) of 3-methylpiperidine and 2.5 g. (0.01 mole) of 3-chloro-5-chlorosulfonylbenzoic acid in 15 ml. of methylene chloride, providing 2.7 g., m.p. 177°-179° C. of the crude product. Purification is effected by recrystallization from acetone-hexane, 1.2 g.,m.p. 181°-183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03992441 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-c00072df2cbf494b9d1dfe2c09dcc8d4 |
| Source note | uspto-grants-1976_11 |