HCID 3042139, compound → HCID 12255293, compound

HRID 1730631Notes

Reaction equation

HRID 1730631 reaction equation
[C:1]([C:5]1[NH:6][C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:8]2[C:13]=1[C:12](=[O:14])[NH:11][C:10](=[O:15])[NH:9]2)([O:3][CH3:4])=[O:2].NC1C([C:28](OC)=[O:29])=C(C(OC)=O)NC=1C1C=CC=CC=1.[N-]=C=O.[Na+]>>[C:12]([C:13]1[C:8]([NH:9][C:10]([NH2:11])=[O:15])=[C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[NH:6][C:5]=1[C:1]([O:3][CH3:4])=[O:2])([O:29][CH3:28])=[O:14]

Participants

4

Reactant 3

HCID 3042139HCID 3042139, compoundHCID 30445191H-Pyrrolo(3,4-d)pyrimidine-5-carboxylic acid, 2,3,4,6-tetrahydro-2,4-dioxo-7-phenyl-, methyl esterHCID 11051568NaNCO

Product 1

HCID 12255293HCID 12255293, compound

Procedure

5-Carbomethoxy-7-phenyl-6H-pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione, from 3-amino-4,5-dicarbomethoxy-2-phenyl-pyrrole and sodium isocyanate. The intermediate 4,5-dicarbomethoxy-2-phenyl-3-ureido-pyrrole is isolated. M.p. 246°-8° C (from methanol/water). Yield of the title compound 88.5%. M.p. 320°-7° C. (from methanol/water).

Sources & evidence

ORD record
ord-5c3fc643b43d437cb34f79c59fa5c466
Source dataset
uspto-grants-1976_11
Patent number
US03993650

Reaction notes

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