Diethyl Sulfate → HCID 12495247, compound

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Reaction Steps

Compound B) is transformed into the corresponding p-toluene sulfonamido derivative (M.p. 230°-33° C) by reaction with p-toluenesulfonychloride. This compound is subsequently reacted in strong alkaline solution with diethylsulfate, thus obtaining 4-benzoyl-3-(N-ethyl-p-toluenesulfonamido)-5-methyl-2-phenyl-pyrrole (M.p. 152°-53° C), which is in turn converted into the title compound (B.p. 220° C/0.015 mmHg) by acid hydrolysis.

Provenance & Evidence