Sodium Hydroxide → HCID 54540738, compound

HRID 1730656Notes

Reaction equation

HRID 1730656 reaction equation
F[B-](F)(F)F.[CH3:6][N:7]([CH3:25])[CH:8]=[C:9]([C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16](C=O)[CH:15]=1)[CH:10]=[N+](C)C.[OH-:26].[Na+]>>[CH3:6][N:7]([CH3:25])[CH:8]=[C:9]([C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1)[CH:10]=[O:26]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86734208HCID 86734208, compound

Product 1

HCID 54540738HCID 54540738, compound

Procedure

The trimethinium salt obtained in Step A (990 mg., 3 mmole) is stirred with 1N sodium hydroxide solution at 70° C. for one hour. The solid is filtered off and washed with water yielding 564 mg. (88%) of compound, m.p. 188°-190° C. (dec.). Recrystallization of the crude product from alcohol (11.5 ml.) affords the pure compound crystallizing in cream-colored prisms, m.p. 191°-192° C. with slight darkening.

Workup

  1. filtrationThe solid is filtered off
  2. washwashed with water yielding 564 mg
  3. customRecrystallization of the crude product from alcohol (11.5 ml.)
  4. customaffords the pure compound
  5. customcrystallizing in cream-colored prisms, m.p. 191°-192° C. with slight darkening

Sources & evidence

ORD record
ord-e3b22198b8d7408998c60932c0c9156b
Source dataset
uspto-grants-1976_11
Patent number
US03993656

Reaction notes

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