Methanol → HCID 54191689, compound

Participants

Reaction Steps

A solution of 1.53 gm (5 millimols) of [1-(2-fluoro-4-biphenylyl)-ethylsulfinyl]-acetic acid, m.p. 161°-163° C, in 15 ml of benzene was admixed with 0.24 gm (7.5 millimols) of methanol, and then a solution of 1.25 gm (6 millimols) of dicyclohexyl-carbodiimide in 5 ml of benzene was added. After stirring for one hour, the precipitated dicyclohexylurea was suction-filtered off, the filtrate was evaporated, and the residue was purified by chromatography on 300 gm of silicagel with cyclohexane/ethyl acetate = 1/4. Yield: 1.4 gm (87.6% of theory); oil, Rf -value: 0.5 on carrier 1 with cyclohexane/ethyl acetate = 1/4.

Provenance & Evidence