Potassium Permanganate → HCID 53906677, compound

Participants

Reaction Steps

A suspension of 2.1 gm (13.4 millimols) of potassium permanganate in 15 ml of water was added in small portions to a slution of 5.0 gm (13.4 millimols) of [1-(2'-fluoro-4-biphenylyl)-ethylsulfinyl]-acetic acid piperidide in 30 ml of glacial acetic acid. The temperature was maintained at 15°-20° C. The mixture was stirred for 1 hour at room temperature, then diluted with water, the manganese dioxide was reduced with sodium bisulfite, and the reaction product was extracted with ethyl acetate. After washing, drying and evaporation of the ethyl acetate extract, the residue was recrystallized from isopropanol. Yield: 65% of theory; m.p. 126° C.

Provenance & Evidence