Methanol → HCID 53776172, compound

Participants

Reaction Conditions

Reaction Steps

17.0 gm (56 millimols) of [1-(4-biphenylyl)-ethyl-sulfonyl]-acetic acid were dissolved in 100 ml of methanol, and 3 ml of phosphorus oxychloride were added to the solution while cooling on ice. The mixture was heated to 35° C and was then allowed to stand overnight at room temperature. The crystalline reacton product which had separated out was suction-filtered off and recrystallized from 50 ml of isopropanol. Yield: 14.8 gm (83% of theory); m.p. 79°-80° C.

Provenance & Evidence