Hydrazine hydrate (1:1) → 6-Chloro-2-hydrazinyl-4-phenylquinoline

Participants

Reaction Steps

A stirred mixture of 2,6-dichloro-4-phenylquinoline (2.7 g., 0.01 mole) and hydrazine hydrate (6.8 g.) was refluxed under nitrogen for 1 hour and concentrated in vacuo. The residue was suspended in warm water, and the solid was collected by filtration, dried and recrystallized from ethyl acetate-Skelly B hexanes to give 1.81 g. (67%) yield) of 6-chloro-2-hydrazino-4-phenylquinoline of melting point 156.5°-157° C.

Provenance & Evidence