反应详情

57 parts (by weight) of N-cyclohexylhydroxylamine hydrochloride is added to 800 parts of benzene; 71 parts of triethylamine is then introduced into this mixture. After the mixture has been stirred for 1 hour, a solution of 50 parts of 2-methylfuran-3-carboxylic chloride in 100 parts of benzene is dripped in at room temperature. After the mixture has been stirred for 3 hours the precipitate is filtered and washed with benzene. The filtrate is washed with water, dried over sodium sulfate and evaporated. The crystalline residue is recrystallized from cyclohexane. There is obtained 33 parts of N-cyclohexyl-2-methylfuran-3-hydroxamic acid, m.p.: 108°-110° C.

1. customis dripped in at room temperature
2. stirringAfter the mixture has been stirred for 3 hours the precipitate
3. filtrationis filtered
4. washwashed with benzene
5. washThe filtrate is washed with water
6. dry with materialdried over sodium sulfate
7. customevaporated
8. customThe crystalline residue is recrystallized from cyclohexane