Dimethylhydantoin → 3-(4-Chlorobutyl)-5,5-dimethyl-hydantoin

Participants

Reaction Steps

A mixture of 538 g of 5,5-dimethyl-hydantoin (4.2 mols), 290 g of anhydrous potassium carbonate (2.1 mols) and 2,130 g of 1,4-dichlorobutane (16.77 mols) is reacted for 8 hours at 138° to 141° C internal temperature (external temperature 200° C), as described under Example 1 (a). Working up is carried out according to Example 1 (a), and 830.9 g of a brown, viscous crude product (90.5% of theory) are obtained, and are purified by vacuum distillation (boiling point0.2 : 151°-153° C) and subsequent recrystallisation from diethyl ether. The pure product melts at 54.4° to 56.3° C.

Provenance & Evidence