HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-((Acetyloxy)methyl)-7-amino-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid → HCID 21493865, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-((Acetyloxy)methyl)-7-amino-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid | HCID 13729 | — |
| Reactant | 5-Chloromethyl-2-thienylacetyl chloride | HCID 22767753 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 21493865 | HCID 21493865 | — |
Reaction Steps
A mixture of 1.2 equivalents of 5-chloromethyl-2-thienylacetyl chloride and 1 equivalent of 3-[(acetyloxy)-methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is refluxed for 50 minutes in ethyl acetate after which the solvent is removed and the remaining product is purified by column chromatography on silica gel to give 3-[(acetyloxy)methyl]-7-[[2-[5-(chloromethyl)-2-thienyl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994875 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-e377d1e51efd4e079b01ad793f037b04 |
| Source note | uspto-grants-1976_11 |