HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → Cephalosporanic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | 7-Aminocephalosporanic acid | HCID 441328 | — |
| Product | Cephalosporanic Acid | HCID 12302722 | — |
Reaction Steps
reaction of 7-ACA with phosgene (or thiophosgene) to yield isocyanato (or isothiocyanato) cephalosporanic acid which is reacted with the appropriate amine of formula R1NH2 and then either catalytic hydrogenation of the 3-acetoxy group to yield the 3-methyl group or displacement of the 3-acetoxy group of 7-ACA with the desired mercaptoheterocyclic compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994886 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-e7b96a48526b443a878d878430b27eb1 |
| Source note | uspto-grants-1976_11 |