Ammonia → Ethyl 4-aminopyrazolo[1,5-a]quinoxaline-3-carboxylate

HRID 1730868Notes

Reaction equation

HRID 1730868 reaction equation
C([NH:5][C:6]1[C:7]2[N:8]([N:16]=[CH:17][C:18]=2[C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:9]2[C:14]([N:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)CCC.N>>[NH2:5][C:6]1[C:7]2[N:8]([N:16]=[CH:17][C:18]=2[C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:9]2[C:14]([N:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2

Participants

3

Reactant 2

HCID 222AmmoniaHCID 92039457HCID 92039457, compound

Product 1

HCID 71390467Ethyl 4-aminopyrazolo[1,5-a]quinoxaline-3-carboxylate

Procedure

2,76 g. of the chloro compound of Example 1 c is stirred for 10 hours with 25 ml. of saturated alcoholic ammonia solution at room temperature. The product, 4-aminopyrazolo[1,5-a]quinoxaline-3-carboxylic acid, ethyl ester, is obtained as a white precipitate which is filtered under suction, treated with water and recrystallized from ethanoldimethylformamide; yield 1.76 g., m.p. 235°-237°.

Workup

  1. customat room temperature

Sources & evidence

ORD record
ord-e7c71774e1cc41eea1708b179d0a1306
Source dataset
uspto-grants-1976_11
Patent number
US03994893

Reaction notes

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