Triphenylphosphine → HCID 88802302, compound

Participants

Reaction Steps

A solution of triphenylphosphine (0.99 g, 1.5 equiv.) in ethyl acetate (10 ml) was added to a stirred solution of diphenylmethyl 3-bromomethyl-7β-phenoxyacetamidoceph-3-em-4-carboxylate (ca. 1.49 g, 2.515 mmole) in ethyl acetate (25 ml). The mixture was stirred in the absence of light for 16 hours, and the precipitated solid was filtered off, washed with ethyl acetate and dried to give the title phosphonium salt (1.585 g, 74%), λmax. (EtOH) 268.5 nm (ε 10,700) and 275.5 nm(ε 9,850), νmax. (CHBr3), 3415 (NH), 1788 (azetidin-2-one), 1710 (CO2R), 1692 and 1620 (CONH) and 1440 cm-1 (P+-C6H5).

Provenance & Evidence