1-Chloro-2-(diethylamine)ethane hydrochloride → 1-Diethylaminoethyl-3-phenyl-5-chloroindazole hydrochloride

HRID 1730925Notes

Reaction equation

HRID 1730925 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:18]([N:20]([CH2:23][CH2:24]Cl)[CH2:21][CH3:22])[CH3:19]>>[ClH:16].[CH2:18]([N:20]([CH2:23][CH3:24])[CH:21]([C:14]1[C:13]([Cl:16])=[CH:12][CH:11]=[C:10]2[C:15]=1[C:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[N:8][NH:9]2)[CH3:22])[CH3:19]

Participants

3

Reactant 2

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 6151185-Chloro-3-phenyl-1H-indazole

Product 1

HCID 681383821-Diethylaminoethyl-3-phenyl-5-chloroindazole hydrochlorideYield 140.1%

Procedure

By the procedure similar to that described in Example 1, 3-phenyl-5-chloroindazole (4.57 g) and diethylaminoethyl chloride hydrochloride (5.16 g) were treated to obtain 5.1 g of 1-diethylaminoethyl-3-phenyl-5-chloroindazole hydrochloride (m.p. 185°-186° C).

Workup

  1. additionwere treated

Sources & evidence

ORD record
ord-7b8b15c2d0f946e18392f9b4d1c4f08a
Source dataset
uspto-grants-1976_11
Patent number
US03994890

Reaction notes

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