4-(2-Chloroethyl)morpholine → 1-Morpholinoethyl-3-phenyl-5-chloroindazole hydrochloride

HRID 1730935Notes

Reaction equation

HRID 1730935 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24]Cl)[CH2:19][CH2:18]1>>[ClH:16].[O:17]1[CH2:22][CH2:21][N:20]([CH:23]([C:14]2[C:13]([Cl:16])=[CH:12][CH:11]=[C:10]3[C:15]=2[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8][NH:9]3)[CH3:24])[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 767274-(2-Chloroethyl)morpholineHCID 6151185-Chloro-3-phenyl-1H-indazole

Product 1

HCID 681390481-Morpholinoethyl-3-phenyl-5-chloroindazole hydrochloride

Procedure

By the procedure similar to that described in Example 13, 3-phenyl-5-chloroindazole (4.57 g) and morpholinoethyl chloride (3.59 g) were treated to obtain 3.7 jg of 1-morpholinoethyl-3-phenyl-5-chloroindazole hydrochloride (m.p. 226°-229° C).

Workup

  1. additionwere treated

Sources & evidence

ORD record
ord-b0044aa7100b4daf9e016153fc45684a
Source dataset
uspto-grants-1976_11
Patent number
US03994890

Reaction notes

Loading…