5-Methyl-3-phenyl-1H-indazole → HCID 68139930, compound

HRID 1730936Notes

Reaction equation

HRID 1730936 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH3:16])[CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:17]1[CH2:22][CH2:21][N:20]([CH:23]([Cl:26])[CH2:24][CH3:25])[CH2:19][CH2:18]1>>[ClH:26].[O:17]1[CH2:22][CH2:21][N:20]([CH:23]([C:14]2[C:13]([CH3:16])=[CH:12][CH:11]=[C:10]3[C:15]=2[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:8][NH:9]3)[CH2:24][CH3:25])[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 6104125-Methyl-3-phenyl-1H-indazoleHCID 22170244HCID 22170244, compound

Product 1

HCID 68139930HCID 68139930, compoundYield 55.1%

Procedure

By the procedure similar to that described in Example 13, 3-phenyl-5-methylindazole (4.17 g) and 1-morpholinopropyl chloride (3.93 g) were treated to obtain 4.1 g of 1-morpholinopropyl-3-phenyl-5-methylindazole hydrochloride (m.p. 180°-182° C).

Workup

  1. additionwere treated

Sources & evidence

ORD record
ord-78e56e5e427e444d8fc8d20a3176396a
Source dataset
uspto-grants-1976_11
Patent number
US03994890

Reaction notes

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