HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1-Hydroxymethyl-3-phenylindazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-phenyl-1H-indazole | HCID 300385 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Hydroxymethyl-3-phenylindazole | HCID 13292584 | 77.6% |
Reaction Steps
3-Phenylindazole (9.71 g), paraformaldehyde (2.25 g) and 5% aqueous sodium hydroxide solution (1 ml) were added to ethanol (40 ml) and the mixture was heated under reflux for 3 hours. After cooling the reaction mixture, the precipitated crystals were recovered by filtration to obtain 8.7 g of 1-hydroxymethyl-3-phenylindazole having a melting point between 103°-105° C after recrystallization from ligroine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994890 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-969ed7aa68484e108babc158379aa2fe |
| Source note | uspto-grants-1976_11 |