Formaldehyde → HCID 21494230, compound

HRID 1730941Notes

Reaction equation

HRID 1730941 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH3:16])[CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]=[O:18]>>[OH:18][CH2:17][N:9]1[C:10]2[C:15](=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:8]1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 6104125-Methyl-3-phenyl-1H-indazole

Product 1

HCID 21494230HCID 21494230, compoundYield 83.6%

Procedure

By the procedure similar to that described in Example 19, 3-phenyl-5-methylindazole (13.7 g) and paraformaldehyde (2.4 g) were treated to obtain 13.1 g of 1-hydroxymethyl-3-phenyl-5-methylindazole (m.p. 109°-111° C).

Workup

  1. additionwere treated

Sources & evidence

ORD record
ord-655957c338db4f1a9d40e55c3c617dd5
Source dataset
uspto-grants-1976_11
Patent number
US03994890

Reaction notes

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