反应详情

1-Hydroxymethyl-3-phenylindazole (2 g), morpholine (0.84 g) and 5% aqueous sodium hydroxide solution (1 ml) were dissolved in ethanol (30 ml), and the mixture was heated under reflux for 3 hours. After completion of the reaction, the mixture was concentrated under reduced pressure. The resulting oily residue was treated with ether-hydrochloric acid to obtain 1-morpholinomethyl-3-phenylindazole having a melting point between 166°-167° C (decomposition) after recrystallization from ethanol-ether.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hours
3. customAfter completion of the reaction
4. concentrationthe mixture was concentrated under reduced pressure
5. additionThe resulting oily residue was treated with ether-hydrochloric acid