反应详情

温度

70 °C

3-Phenyl-5-chloroindazole (4.57 g), piperidinoethyl chloride (3.6 g), and triethylbenzylammonium chloride (0.5 g) were added to 50% aqueous sodium hydroxide solution (5 ml) followed by stirring at 70° C for 1 hour. After completion of the reaction, the mixture was extracted with benzene and the extract was washed with water, dried over sodium sulfate and concentrated. The residue was treated with ethanol-hydrochloric acid to obtain 4.3 g of 1-piperidinoethyl-3-phenyl-5-chloroindazole hydrochloride having a melting point between 230°-235° C after recrystallization from acetone.

1. customAfter completion of the reaction
2. extractionthe mixture was extracted with benzene
3. washthe extract was washed with water
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. additionThe residue was treated with ethanol-hydrochloric acid