Piperidine → 7-Methoxy-3-[3-phenyl-1,2,4-oxadiazol-5-yl]coumarin

Participants

Reaction Steps

7.6 parts of 2-hydroxy-4-methoxy benzaldehyde and 11.6 parts of the ethyl ester of 3-phenyl-1,2,4-oxadiazole-5-acetic acid (boiling point: 150° C/0.5 mm) are dissolved in 80 parts of toluene. 0.5 part of piperidine is added and the mixture is heated under reflux for 1 hour. The mixture is cooled, the crystallized product is filtered and then washed in ethanol. 13.7 parts of 7-methoxy 3-(3-phenyl 1,2,4-oxadiazol-5-yl) coumarin are obtained which, after crystallization in an ethanol-dioxane mixture, melts at 215° C.

Provenance & Evidence